‘Betrinac reduces blood levels of homocysteine, which helps maintain brain performance and memory as you get older.’

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Ageing is associated with damaging ‘free radicals’ and decreased cell defences. This ‘oxidative stress’ is implicated in dementia and contributes to brain degeneration.

Two enzymes break down homocysteine – methionine synthase (MS) and cystathionine beta-synthase (CBS). They respond differently to oxidative stress. MS activity decreases but CBS activity increases. This diverts homocysteine toward synthesis of glutathione – a powerful antioxidant

However, nerve cells cannot fully convert homocysteine to glutathione and are vulnerable to oxidative damage. Vitamin B12 and folate, the cofactors for MS activity, are also easily oxidised.

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Cobalz solved this problem by raising levels of the antioxidant glutathione. Although glutathione is not absorbed from the gut, its levels can be increased by giving N-acetylcysteine (NAC). When given together with B vitamins and folic acid, NAC improves symptoms in patients with raised homocysteine and memory impairment.

This novel approach forms the basis of Cobalz’s platform technology.

 
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