‘Betrinac reduces blood levels of homocysteine, which helps maintain brain performance and memory as you get older.’

Intellectual property

Ageing is associated with damaging ‘free radicals’ and decreased cell defences. This ‘oxidative stress’ is implicated in dementia and contributes to brain degeneration.

Two enzymes break down homocysteine – methionine synthase (MS) and cystathionine beta-synthase (CBS). They respond differently to oxidative stress. MS activity decreases but CBS activity increases. This diverts homocysteine toward synthesis of glutathione – a powerful antioxidant

However, nerve cells cannot fully convert homocysteine to glutathione and are vulnerable to oxidative damage. Vitamin B12 and folate, the cofactors for MS activity, are also easily oxidised.


Cobalz solved this problem by raising levels of the antioxidant glutathione. Although glutathione is not absorbed from the gut, its levels can be increased by giving N-acetylcysteine (NAC). When given together with B vitamins and folic acid, NAC improves symptoms in patients with raised homocysteine and memory impairment.

This novel approach forms the basis of Cobalz’s platform technology.


Cobalz Limited
12A White Friars
United Kingdom


General information

Product information


0844 9 400 400