News & Publications

Research publications and scientific abstracts

Publications

McCaddon A, Hudson P (2010) L-methylfolate, Methylcobalamin and N-acetylcysteine in the treatment of Alzheimer’s disease-related cognitive decline CNS Spectrums 15 (Suppl 1): 1-6

Suarez-Moreira E, Yun J, Birch CS, Williams JH, McCaddon A, Brasch NE (2009) Vitamin B12 and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD) J Am Chem Soc 131(42): 15078-9

Mukherjee R, McCaddon A, Smith CA, Brasch NE (2009) Synthesis, synchrotron X-ray diffraction, and kinetic studies on the formation of a novel thiolatocobalamin of captopril: evidence for cis-trans isomerization in the beta-axial ligand Inorg Chem 48(19): 9526-34

Birch CS, Brasch NE, McCaddon A, Williams JH (2009) A novel role for vitamin B12: Cobalamins are intracellular antioxidants in vitro Free.Radic.Biol.Med. 47(2):184 - 188

McCaddon A, Hudson P (2007) Alzheimer’s disease, oxidative stress and B-vitamin depletion Future Neurology 2(5):537-47

Obeid R, McCaddon A, Herrmann W (2007) The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Clin.Chem.Lab.Med. 45(12):1590 - 606

McCaddon A, Hudson P (2007) Methylation and phosphorylation: a tangled relationship. Clin.Chem. 53(6): 999 - 1000

McCracken C, Hudson P, Ellis R, McCaddon A (2006) Methylmalonic acid and cognitive function in the MRC Cognitive Function and Aging Study. Am.J.Clin.Nutr. 84 1406 - 1411

McCaddon A, (2006) Homocysteine and cognition - a historical perspective. Journal of Alzheimer’s Disease 9(4): 361-380

McCaddon A, (2006) Homocysteine and cognitive impairment; a case series in a General Practice setting. Nutrition Journal 5 (6)

McCaddon A, Davies G (2005) Co-administration of N-acetylcysteine, vitamin B12 and folate in cognitively impaired hyperhomocysteinaemic patients. Int.J.Ger.Psych. 20 (10):998-1000

McCaddon A, Regland B (2006) Homocysteine and cognition – no longer a hypothesis? Med Hypotheses. 66 (3):682-3

McCaddon A, Davies G (2005) Clinical effects of co-administering N-acetylcysteine, vitamin B12 and folate in cognitively impaired hyperhomocysteinaemic patients. Haematologica Reports 1(3):49-50

Zetterberg H, Nexo E, Minthon L, Boson R, Regland B, McCaddon A, Blennow K. (2005) The transcobalamin 776 C>G polymorphism may be a modifiable genetic risk factor for Alzheimer’s disease. International Psychogeriatrics 17(2):329-31

McCaddon A, Everall M, Hudson P et al (2005) Cobalamin analogues and Alzheimer’s Disease. (In preparation)

McCaddon A. (2005) Homocysteine and Cognition – ‘Mechanisms’ (Plenary Session of the 4th International Homocysteine Conference – Basel, 2003) in “Homocysteine Metabolism” (editor B.Fowler) SPS Publications: 109-122

McCaddon A, Tandy S, Hudson P et al (2004) Absence of macrocytic anaemia in Alzheimer’s Disease Clin Lab Haematol. 2004 Aug;26(4):259-63

McCaddon A, Blennow K, Hudson P, et al (2004) Transcobalamin Polymorphism and Serum Holo-Transcobalamin in Relation to Alzheimer’s Disease Dement Geriatr Cogn Disord. 17:215-221

Vidal-Alaball J, Butler C, Hood K, Cannings R, McCaddon A, Papaioannou A. Oral vitamin B12 versus parenteral vitamin B12 for vitamin B12 deficiency (Protocol for a Cochrane Review) Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004655.

McCaddon A, Hudson P, Hill D, Barber J, Lloyd A, Davies G, Regland B. (2003) Alzheimer’s Disease and total plasma aminothiols Biological Psychiatry. 53 (3): 254-260

Vascular Disease, Parkinson’s, and now Alzheimer’s - Is Homocysteine the new all-around bad guy? (2003) Journal of Alzheimer’s Disease 5: 161-168

McCaddon A, Hudson P, McCracken C, Ellis R, McCaddon A. (2003) Biological variation of holo-transcobalamin in elderly individuals Clin Chem 49 (9): 1542-1544

McCaddon A, Regland B, Hudson P, Davies G. (2002) Functional vitamin B12 deficiency and Alzheimer’s Disease Neurology 58: 1395-1399

McCaddon A, Hudson P, Ellis D, Hill D, Lloyd A. (2002) Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12 Lancet 360: 173

McCaddon A, Blennow K, Hudson P, Regland B. (2001) Transcobalamin Polymorphism and Homocysteine Blood 98: 3497-3499

McCaddon A, Hudson P, Davies G, Hughes A, Williams J, Wilkinson C. (2001) Homocysteine and cognitive decline in healthy elderly Dem.Ger.Cog.Dis. 12: 309-313

McCaddon A, Hudson P, Abrahamsson, L. Oloffson, H. Regland B. (2001) Analogues, ageing, and aberrant assimilation of vitamin B12 in Alzheimer’s Disease Dem.Ger.Cog.Dis. 12: 133-137

McCaddon A, Davies G, Hudson P. (2000) Nutritionally independent B12 deficiency in Alzheimer Disease Arch.Neurol. 57: 607-608

McCaddon A, Davies G, Hudson P, Tandy S, Cattell H. (1998) Total serum homocysteine in Senile Dementia of Alzheimer Type Int.J.Ger.Psych. 13: 235-239

McCaddon A, Kelly CL. (1994) Familial Alzheimer’s Disease and vitamin B12 deficiency Age Ageing. 23: 334 -337

Kennedy AM, Newman S, McCaddon A, et al. (1993) Familial Alzheimer’s Disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine > glycine) Brain. 116: 309 - 324

McCaddon A, Kelly CL. (1992) Alzheimer’s Disease: A ‘cobalaminergic’ hypothesis Med Hypoth. 37: 161 - 165

Abstracts presented at scientific meetings

McCracken C, Hudson P, Ellis R, McCaddon A. (2006) Vitamin B12 and folate status as independent determinants of cognitive function in the MRC cognitive function and ageing study. FASEB Summer Research Conference August 5th-10th 2006

Hill D, Johnson L, Hudson P, McCaddon A, Kenney A. (2003) Homocysteine export from erythrocytes in stored whole blood. J. Inherit. Metab. Dis. 26 Suppl 1 Abstract 146 Pg 112.

McCaddon A, Hudson P, Davies G, Hughes A, Williams J, Wilkinson C. (2001) Homocysteine and cognitive decline over 5 years in healthy elderly individuals. 3rd International Conference on Homocysteine Metabolism. Abstract No. 185, Pg 133

McCaddon A, Blennow K, Regland B, Kenney A, Hill D, Hudson P, Lloyd A, Davies G. (2001) Transcobalamin isotype and serum homocysteine in the elderly. 3rd International Conference on Homocysteine Metabolism. Abstract No. 60, Pg 63.

McCaddon A, Hudson P, Hill D, Kenney A, Hughes A, Barber J, Gray R, Tandy S. (2001) Hyperhomocysteinemia and oxidative stress – a pathogenic mechanism common to Alzheimer’s and Vascular Disease? 3rd International Conference on Homocysteine Metabolism. Abstract No. 181, Pg 131

McCaddon A. (2001) Vitamin B12 and cognition – Mind over Marrow? 6th meeting of “Advancing Laboratory Practice in Haematology,” Jersey.

McCaddon A, Hudson P, Hill D, Barber J, Lloyd A, Davies G, Regland B. (2001) Alzheimer’s Disease and total plasma aminothiols – Fire and Brimstone? The 3rd Welsh Primary Care Research Symposium, Llandrindod Wells.

Davies G, McCaddon A, Hudson P, Tandy S, Cattell H. (1999) Total serum homocysteine in senile dementia of Alzheimer-type. Proc.A.C.B. National Meeting: (ISSN:0959-9029) 102-103.

McCaddon A. (1999) Vitamin B12 deficiency and dementia. The 1st Welsh Primary Care Research Symposium, Llandrindod Wells.

 
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